ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

Base Information

• Chemical Name: ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid
• CAS No.: 148926-95-8
• Molecular Formula: C₁₅H₁₄Cl₂N₂O₅
• Molecular Weight: 373.193
• Mol file: 148926-95-8.mol

Synonyms:ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

Chemical Property of ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

There total 8 articles about ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid (148926-94-7) + Cyclopropylamine (765-30-0) → ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid (148926-95-8)

Guidance literature:

In diethyl ether; ethanol; for 0.25h; Ambient temperature;

DOI:10.1021/jm00006a017

Reference yield:

2,4-dichloro-5-nitro benzoyl chloride (713-28-0) → ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid (148926-95-8)

Guidance literature:

Multi-step reaction with 3 steps

2: 90 percent / 5 h / 20 °C

3: ethanol / 2 h / 20 °C

In ethanol; 1: Acylation / 2: Substitution / 3: Substitution;

DOI:10.1007/BF02464110

Reference yield:

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) → ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid (148926-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / 1 h / 90 °C

2: 94 percent / ethanol; diethyl ether / 0.25 h / Ambient temperature

With triethylamine; In diethyl ether; ethanol; toluene;

DOI:10.1021/jm00006a017

upstream raw materials:

ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

Cyclopropylamine

ethyl ester of (5-nitro-2,4-dichlorobenzoyl)acetic acid

orthoformic acid triethyl ester

Downstream raw materials:

ethyl ester of 1-cyclopropyl-6-nitro-4-oxo-7-chloro-1,4-dihydroquinoline-3-carboxylic acid