713-28-0

Upstream product

• 13014-18-1 2,4-dichlorobenzotrichloride 
• 717-43-1 2,4-Dichlor-5-nitrophenylchloroform 
• 19861-62-2 2,4-dichloro-5-nitrobenzoic acid 

Downstream Products

• 174312-93-7 ethyl ester of (5-nitro-2,4-dichlorobenzoyl)acetic acid 
• 1028202-71-2 ethyl 3-(benzothiazol-2-yl)-4-(2,4-dichloro-5-nitrophenyl)-2,4-dioxobutanoate 
• 161040-64-8 1-(4-Fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-65-9 1-(4-Fluoro-phenyl)-6-nitro-4-oxo-7-thiomorpholin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-82-0 6-Amino-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-32-0 (Z)-2-(2,4-Dichloro-5-nitro-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid ethyl ester 
• 162558-46-5 6-Amino-1-(4-fluoro-phenyl)-4-oxo-7-thiomorpholin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 148927-35-9 ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 161040-31-9 (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester 
• 161040-76-2 6-Amino-1-tert-butyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-78-4 6-Amino-1-tert-butyl-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 173061-62-6 ethyl ester of 3-ethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid 
• 148926-95-8 ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid 
• 148926-94-7 ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid 

Relevant academic research and scientific papers

2-Halobenzoyl chlorides in the synthesis of [1,3,4]thiadiazolo[3,2-a]quinazolin-5-one derivatives

New nitro and sulfonamide derivatives of [1,3,4]thiadiazolo[3,2-a]quinazolin-5-one have been synthesized by cyclocondensation of 1,3,4-thiadiazol-2-amines with 2-halobenzoyl chlorides containing electron-withdrawing substituents in positions 3, 4, and 5. An improved procedure has been proposed for the preparation of intermediate 2-fluoro-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamides containing a sulfamoyl group in the 5-position via selective acylation of 5-methyl-1,3,4-thiadiazol-2-amine with 5-chlorosulfonyl-2-fluorobenzoyl chloride, followed by sulfonylation of amines.

6-Aminoquinolones: A new class of quinolone antibacterials?

A series of quinolone- and 1,8-naphthyridone-3-carboxylic acids, designed by previous QSAR studies and characterized by an amino group at the C-6 position instead of the usual fluorine atom, were synthesized for the first time and evaluated for in vitro antibacterial activity. All of the synthesized compounds maintain good activity against Gram-negative bacteria (Pseudomonas aeruginosa excluded), and those compounds having a thiomorpholine group as the C-7 substituent also have good activity against Gram-positive bacteria. Some aspects of structure activity relationships associated with the C-1, C-5, C-7, and C-8 substituents are also discussed. Derivatives 18g and 38g displayed the best activity with geometric mean MICs of 0.45 and 0.66-0.76 μg/mL against Gram-negative and Gram-positive bacteria, respectively. This antimicrobial activity reflects their ability to inhibit bacterial DNA-gyrase. The results of this study show that, while the C-6 fluorine is still the preferred substituent, good activity can still be obtained by replacing it with an amino group.