C₄₃H₅₄N₄O₉S₄

Base Information

• Chemical Name: C₄₃H₅₄N₄O₉S₄
• CAS No.: 271253-08-8
• Molecular Formula: C₄₃H₅₄N₄O₉S₄
• Molecular Weight: 899.187
• Mol file: 271253-08-8.mol

Synonyms:C₄₃H₅₄N₄O₉S₄

Chemical Property of C₄₃H₅₄N₄O₉S₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₅₄N₄O₉S₄

There total 11 articles about C₄₃H₅₄N₄O₉S₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal (123064-58-4) + C27H34N2O6S2 (261900-35-0) → C43H54N4O9S4 (271253-08-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.3987/COM-99-S116

Reference yield:

5-fluoro-2-nitrobenzoic acid (320-98-9) → C43H54N4O9S4 (271253-08-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: thionyl chloride / benzene / 1 h / Heating

2.1: triethylamine / tetrahydrofuran; H₂O / 0.67 h / 0 - 20 °C / pH 8.5 - 9.0

3.1: (COCl)2 / CH₂Cl₂ / 1.5 h / Heating

3.2: 1 h / 0 - 20 °C

4.1: LAH / tetrahydrofuran / 1.17 h / -30 °C

4.2: 53 percent / ammonium chloride / tetrahydrofuran / -30 °C

5.1: 89 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - 0 °C

6.1: CH₂Cl₂ / 0.5 h / 20 °C

6.2: 73 percent / chlorotrimethylsilane / CH₂Cl₂

7.1: sodium hydride / tetrahydrofuran / 1 h / Heating

7.2: 76 percent / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; water; benzene; 5.1: Swern oxidation;

Reference yield:

5-fluoro-2-nitrobenzoyl chloride (394-02-5) → C43H54N4O9S4 (271253-08-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran; H₂O / 0.67 h / 0 - 20 °C / pH 8.5 - 9.0

2.1: (COCl)2 / CH₂Cl₂ / 1.5 h / Heating

2.2: 1 h / 0 - 20 °C

3.1: LAH / tetrahydrofuran / 1.17 h / -30 °C

3.2: 53 percent / ammonium chloride / tetrahydrofuran / -30 °C

4.1: 89 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - 0 °C

5.1: CH₂Cl₂ / 0.5 h / 20 °C

5.2: 73 percent / chlorotrimethylsilane / CH₂Cl₂

6.1: sodium hydride / tetrahydrofuran / 1 h / Heating

6.2: 76 percent / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; water; 4.1: Swern oxidation;

upstream raw materials:

N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

C₂₇H₃₄N₂O₆S₂

5-fluoro-2-nitrobenzoic acid

5-fluoro-2-nitrobenzoyl chloride