2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester

Base Information

• Chemical Name: 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester
• CAS No.: 129222-62-4
• Molecular Formula: C₂₀H₂₂O₄S
• Molecular Weight: 358.458
• Mol file: 129222-62-4.mol

Synonyms:2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester

Chemical Property of 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester

There total 3 articles about 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 2-<(4-methylphenylsulfonyl)methyl>propenoic acid methyl ester (126234-89-7) → 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester (129222-62-4)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 1-<(2-phenylsulfonamido)phenyl>ethanone; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 4h; Inert atmosphere; Irradiation;

DOI:10.1002/chem.201901665

Reference yield:

p-toluenesulfonyl iodide (1950-78-3) → 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester (129222-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) Et₃N / 1.) CCl₄, 20 deg C, light, 2.) CCl₄, reflux, 15 h

2: 58 percent / benzoyl peroxide / CCl₄ / 8 h / Heating

With triethylamine; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1016/S0040-4020(97)00306-2

Reference yield:

sodium 4-methylbenzenesulfinate (824-79-3) → 2-methylene-5-(4-methylphenylsulfonyl)-4-phenylpentanoic acid methyl ester (129222-62-4)

Guidance literature:

Multi-step reaction with 3 steps

1: I₂ / ethanol; H₂O

2: 2.) Et₃N / 1.) CCl₄, 20 deg C, light, 2.) CCl₄, reflux, 15 h

3: 58 percent / benzoyl peroxide / CCl₄ / 8 h / Heating

With iodine; triethylamine; dibenzoyl peroxide; In tetrachloromethane; ethanol; water;

DOI:10.1016/S0040-4020(97)00306-2

upstream raw materials:

styrene

2-<(4-methylphenylsulfonyl)methyl>propenoic acid methyl ester

p-toluenesulfonyl iodide

sodium 4-methylbenzenesulfinate