126234-89-7Relevant academic research and scientific papers
Free radical addition reactions of allylic sulfones to alkenes
Harvey, Iain W.,Phillips, Eifion D.,Whitham, Gordon H.
, p. 6493 - 6508 (2007/10/03)
Intermolecular radical reactions involving formal addition of the sulfonyl and allyl fragments of an allylic sulfone across the double bond of an alkene are described. Reactions are most successful when the allylic sulfone has an electron withdrawing group at the 2-position. Only monosubstituted alkenes give useful yields of adducts, though both electron withdrawing and electron donating substituents are effective.
Intramolecular SH2 macrocyclisations
Baldwin, Jack E.,Adlington, Robert M.,Mitchell, Mark B.,Robertson, Jeremy
, p. 5901 - 5918 (2007/10/02)
The synthesis of 10-15 membered α-methylene macrocyclic lactones from the functionalised allylstannanes (7e)-(7j) is described. Attempts to synthesise analogous 6-9 membered lactones proved unsuccessful, resulting instead in the production of dilactones and AIBN derived adducts.
Radical Reactions in Synthesis: Intramolecular SH2' Macrocyclisations
Baldwin, Jack E.,Adlington, Robert M.,Mitchell, Mark B.,Robertson, Jeremy
, p. 1574 - 1575 (2007/10/02)
The synthesis of 10-15 membered α-methylene lactones 1 from the functionalised allyl stannanes 2 occurs cleanly in moderate to high yield under free radical conditions via an intramolecular SH2' reaction.
SIMPLE SYNTHESIS OF α-METHYLENE ESTERS AND AMIDES FROM METHACRYLIC DERIVATIVES VIA TOSYLATED INTERMEDIATES
Najera, Carmen,Mancheno, Balbino,Yus, Miguel
, p. 3837 - 3840 (2007/10/02)
α-(Tosylmethyl)acrylic acid methyl ester or N-isopropylamide (obtained by a tandem iodosulfonylation-dehydroiodination of methyl methacrylate or N-isopropylacrylamide) react with Grignard reagents or sodium diethyl malonate to give the corresponding α-met
