4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

Base Information

• Chemical Name: 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide
• CAS No.: 1287761-15-2
• Molecular Formula: C₁₈H₁₈N₆O₂S
• Molecular Weight: 382.446
• Mol file: 1287761-15-2.mol

Synonyms:4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

Chemical Property of 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

There total 4 articles about 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide (1287761-15-2)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

With sodium azide; In ethyl acetate; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

4-[3-(3-hydroxypropyl)-5-phenyl-1H-pyrazol-1-yl]benzenesulfonamide → 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide (1287761-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: sodium azide / 1,4-dioxane; water / 6 h / Inert atmosphere; Reflux

With sodium azide; triethylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm2001376

Reference yield:

C19H21N3O5S2 → 4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide (1287761-15-2)

Guidance literature:

With sodium azide; In 1,4-dioxane; water; for 6h; Inert atmosphere; Reflux;

DOI:10.1021/jm2001376

upstream raw materials:

4-hydrazinobenzene-1-sulfonamide hydrochloride

Downstream raw materials:

4-(5-phenyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

4-(3-{3-[3-(2,6-diisopropyl-phenyl)-ureido]-propyl}-5-phenyl-pyrazol-1-yl)-benzenesulfonamide

4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

4-{3-[3-(3-adamantan-1-yl-ureido)-propyl]-5-phenyl-pyrazol-1-yl}-benzenesulfonamide