4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

Base Information

Chemical Name:4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide
CAS No.:1287760-97-7
Molecular Formula:C₂₅H₂₅N₅O₃S
Molecular Weight:475.571
Hs Code.:

Synonyms:4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

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Chemical Property of 4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

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Technology Process of 4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

There total 5 articles about 4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3-[5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]-propyl ammonium chloride

: 103-71-9
phenyl isocyanate

: 1287760-97-7
4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm2001376

Reference yield:

: 4-[3-(3-hydroxypropyl)-5-phenyl-1H-pyrazol-1-yl]benzenesulfonamide

: 1287760-97-7
4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: sodium azide / 1,4-dioxane; water / 6 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm2001376

Reference yield:

: 1287761-15-2
4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

: 1287760-97-7
4-{5-phenyl-3-[3-(3-phenyl-ureido)-propyl]-pyrazol-1-yl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm2001376