2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

Base Information

Chemical Name:2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone
CAS No.:1094044-77-5
Molecular Formula:C₂₅H₂₆BrNO₂
Molecular Weight:452.391
Hs Code.:

Synonyms:2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

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Chemical Property of 2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

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Technology Process of 2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

There total 11 articles about 2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094044-76-4
1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

: 1094044-77-5
2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

Guidance literature:: With pyrrolidone hydrotribromide; In tetrahydrofuran; at 60 ℃; for 0.5h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1094044-77-5
2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: trimethylaluminum / dichloromethane; toluene / 0.25 h / 20 °C

9.1: tetrahydrofuran; diethyl ether / 0 °C

10.1: pyrrolidone hydrotribromide / tetrahydrofuran / 0.5 h / 60 °C

With pyrrolidone hydrotribromide; lithium hydroxide monohydrate; water; hydrogen; iodine; trimethylaluminum; sodium carbonate; caesium carbonate; magnesium; potassium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 1094044-77-5
2-bromo-1-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)ethanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: trimethylaluminum / dichloromethane; toluene / 0.25 h / 20 °C

9.1: tetrahydrofuran; diethyl ether / 0 °C

10.1: pyrrolidone hydrotribromide / tetrahydrofuran / 0.5 h / 60 °C

With pyrrolidone hydrotribromide; lithium hydroxide monohydrate; water; hydrogen; iodine; trimethylaluminum; sodium carbonate; caesium carbonate; magnesium; potassium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;