4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

Base Information

Chemical Name:4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester
CAS No.:1070892-42-0
Molecular Formula:C₂₈H₃₇BClNO₅
Molecular Weight:513.869
Hs Code.:

Synonyms:4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

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Chemical Property of 4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

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Technology Process of 4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

There total 11 articles about 4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070892-41-9
4-{2-[(3-bromo-4-chloro-benzoyl)-methyl-amino]-phenyl}-butyric acid tert-butyl ester

: 73183-34-3
bis(pinacol)diborane

: 1070892-42-0
4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 95 ℃; for 14h;

Reference yield:

: 4424-80-0
2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

: 1070892-42-0
4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 3 h / 20 - 70 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 12 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

4.2: pH ~ 2

5.1: oxalyl dichloride / dichloromethane / 4 h / 0 - 20 °C

6.1: dichloromethane / 20 °C

7.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 95 °C

With lithium hydroxide; oxalyl dichloride; sulfuric acid; water; potassium acetate; sodium hydride; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: C₁₈H₁₆BrCl₂NO₂

: 1070892-42-0
4-(2-{[4-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 95 °C

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane;