2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

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Chemical Name:2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol
CAS No.:1354041-62-5
Molecular Formula:C₂₀H₁₈FN₅O₃
Molecular Weight:395.393
Hs Code.:

Synonyms:2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

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Chemical Property of 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

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Technology Process of 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

There total 3 articles about 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1354041-67-0
ethyl 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-4-hydroxypyrimidine-5-carboxylate

: 75-16-1
methylmagnesium bromide

: 1354041-62-5
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at -20 - 20 ℃; Inert atmosphere;

Reference yield:

: 1354044-05-5
1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride

: 1354041-62-5
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; trimethylaluminum / toluene / 16 h / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridine / 16 h / 110 °C

3: tetrahydrofuran; diethyl ether / 0.5 h / -20 - 20 °C / Inert atmosphere

With pyridine; trimethylaluminum; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/acsmedchemlett.5b00479

Reference yield:

: 1354044-23-7
1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 1354041-62-5
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(2-hydroxypropan-2-yl)pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridine / 16 h / 110 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / -20 - 20 °C / Inert atmosphere

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether;
DOI:10.1021/acsmedchemlett.5b00479