1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

Base Information

Chemical Name:1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide
CAS No.:171070-17-0
Molecular Formula:C₂₃H₃₂N₂O₃
Molecular Weight:384.519
Hs Code.:

Synonyms:1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

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Chemical Property of 1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

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Technology Process of 1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

There total 6 articles about 1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1125-02-6
1-cyano-1-formamidocyclohexane

: 171070-17-0
1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / t-BuOK / tetrahydrofuran / 6 h / Heating

2: 60 percent / diazabicyclo<2.2.2>octane, triethylenediamine, triphosgene / CH₂Cl₂ / 0.5 h / 0 °C

3: methanol / 12 h / Ambient temperature

With 1,4-diaza-bicyclo[2.2.2]octane; bis(trichloromethyl) carbonate; potassium tert-butylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja953868b

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 171070-17-0
1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / aq. NH₄Cl / diethyl ether / 23 °C

2: 53 percent / Ac₂O / 12 h / 23 °C

3: 74 percent / t-BuOK / tetrahydrofuran / 6 h / Heating

4: 60 percent / diazabicyclo<2.2.2>octane, triethylenediamine, triphosgene / CH₂Cl₂ / 0.5 h / 0 °C

5: methanol / 12 h / Ambient temperature

With 1,4-diaza-bicyclo[2.2.2]octane; bis(trichloromethyl) carbonate; potassium tert-butylate; acetic anhydride; ammonium chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja953868b

Reference yield:

: 40652-40-2
N-(cyclohexen-1-yl)formamide

: 171070-17-0
1-[Acetyl-(4-methoxy-benzyl)-amino]-cyclohexanecarboxylic acid cyclohex-1-enylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / diazabicyclo<2.2.2>octane, triethylenediamine, triphosgene / CH₂Cl₂ / 0.5 h / 0 °C

2: methanol / 12 h / Ambient temperature

With 1,4-diaza-bicyclo[2.2.2]octane; bis(trichloromethyl) carbonate; In methanol; dichloromethane;
DOI:10.1021/ja953868b