(7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:(7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine
CAS No.:1429199-84-7
Molecular Formula:C₂₁H₂₆N₄O
Molecular Weight:350.464
Hs Code.:

Synonyms:(7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

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Chemical Property of (7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

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Technology Process of (7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

There total 6 articles about (7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1429199-84-7
(7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzene / 5 h / Reflux

2.1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C

4.2: 48 h / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; benzene;

Reference yield:

: 1086382-78-6
2-bromo-5-cyclopropylpyrazine

: 132715-08-3
(6S,8R)-4-benzyl-8-hydroxy-1,4-diazabicyclo<4.3.0>nonane

: 1429199-84-7
(7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 132715-17-4
(2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate

: 1429199-84-7
(7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

3: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol;