1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

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Chemical Name:1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone
CAS No.:1429296-06-9
Molecular Formula:C₂₃H₂₅F₃N₄O₃
Molecular Weight:462.472
Hs Code.:

Synonyms:1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

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Chemical Property of 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

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Technology Process of 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

There total 5 articles about 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132715-17-4
(2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate

: 1429296-06-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

3: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

4: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

: 132714-97-7
(7R,8aS)-2-benzyl-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

: 1429296-06-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

2: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

3: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 132715-08-3
(6S,8R)-4-benzyl-8-hydroxy-1,4-diazabicyclo<4.3.0>nonane

: 1429296-06-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

2: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 20 °C

With 4-methyl-morpholine; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;