methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

Base Information

Chemical Name:methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate
CAS No.:1257398-00-7
Molecular Formula:C₃₀H₃₁F₄NO₂
Molecular Weight:513.575
Hs Code.:

Synonyms:methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

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Chemical Property of methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

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Technology Process of methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

There total 9 articles about methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1257397-99-1
methyl 2-(4-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-3-(trifluoromethylsulfonyloxy)phenyl)propanoate

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1257398-00-7
methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ml200175q

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257398-00-7
methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 17 h / -78 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

4.1: 4-methyl-1,2,3-trifluorobenzene / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

5.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 4.1: Mannich reaction / 6.1: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: 62969-42-0
3-benzyloxy-phenylacetic acid methyl ester

: 1257398-00-7
methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 17 h / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

3.1: 4-methyl-1,2,3-trifluorobenzene / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 4-methyl-1,2,3-trifluorobenzene; 3.1: Mannich reaction / 5.1: Suzuki coupling;
DOI:10.1021/ml200175q