4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

Base Information

Chemical Name:4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile
CAS No.:1401098-25-6
Molecular Formula:C₂₀H₂₆N₂O₃S
Molecular Weight:374.504
Hs Code.:

Synonyms:4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

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Chemical Property of 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

Chemical Property:

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Technology Process of 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

There total 8 articles about 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 506-68-3
bromocyane

: 1401098-24-5
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

: 1401098-25-6
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 23 ℃; for 1h;

Reference yield:

: 198627-85-9
tert-butyl 4-((4-oxocyclohexyloxy)methyl)piperidine-1-carboxylate

: 1401098-25-6
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2.5 h / -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 23 °C

4.1: triethylamine / dichloromethane / 1 h / 23 °C

With hydrogenchloride; sodium carbonate; triethylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 103-16-2
4-Benzyloxyphenol

: 1401098-25-6
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 - 55 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr

3.1: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr

3.2: 18 h / 23 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 - 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 23 °C

7.1: triethylamine / dichloromethane / 1 h / 23 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; sodium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; rhodium contaminated with carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;