4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

Base Information

Chemical Name:4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride
CAS No.:1401098-24-5
Molecular Formula:C₁₉H₂₇NO₃S*ClH
Molecular Weight:385.955
Hs Code.:

Synonyms:4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

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Chemical Property of 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

Chemical Property:

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Technology Process of 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

There total 7 articles about 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1401097-81-1
tert-butyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

: 1401098-24-5
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 23 ℃; for 2h;

Reference yield:

: 198627-85-9
tert-butyl 4-((4-oxocyclohexyloxy)methyl)piperidine-1-carboxylate

: 1401098-24-5
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2.5 h / -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 23 °C

With hydrogenchloride; sodium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 103-16-2
4-Benzyloxyphenol

: 1401098-24-5
4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 - 55 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr

3.1: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr

3.2: 18 h / 23 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 - 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 23 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; sodium carbonate; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; rhodium contaminated with carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;