methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate

Base Information

• Chemical Name: methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate
• CAS No.: 1341216-70-3
• Molecular Formula: C₂₄H₃₆O₃
• Molecular Weight: 372.548
• Mol file: 1341216-70-3.mol

Synonyms:methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate

Chemical Property of methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate

There total 16 articles about methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

nysted reagent + methyl (2R,3R)-3-methyl-3-(2-oxo-12-phenyldodecyl)oxirane-2-carboxylate (1341216-69-0) → methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate (1341216-70-3)

Guidance literature:

With titanium(IV) dichlorodiisopropylate; In tetrahydrofuran; at 0 - 15 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1260959

Reference yield: 41.0%

dimethyltitanocene (1271-66-5) + methyl (2R,3R)-3-methyl-3-(2-oxo-12-phenyldodecyl)oxirane-2-carboxylate (1341216-69-0) → methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate (1341216-70-3) + C25H38O2 (1341216-75-8)

Guidance literature:

at 80 ℃; for 21h; Inert atmosphere;

DOI:10.1055/s-0030-1260959

Reference yield:

(R)-4-methyl-6-(10-phenyldecyl)-5,6-dihydro-2H-pyran-2-one (1341216-63-4) → methyl (2R,3R)-3-methyl-3-(2-methylene-12-phenyldodecyl)oxirane-2-carboxylate (1341216-70-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; sodium hydroxide / methanol; water / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 2 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: pH 3 - 4 / Inert atmosphere

3.1: diethyl ether; ethyl acetate / 0.17 h / 20 °C / Inert atmosphere

4.1: titanium(IV) dichlorodiisopropylate / tetrahydrofuran / 0 - 15 °C / Inert atmosphere

With titanium(IV) dichlorodiisopropylate; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate;

DOI:10.1055/s-0030-1260959

upstream raw materials:

dimethyltitanocene

methyl (2R,3R)-3-methyl-3-(2-oxo-12-phenyldodecyl)oxirane-2-carboxylate

(R)-4-methyl-6-(10-phenyldecyl)-5,6-dihydro-2H-pyran-2-one

(1R,4R,6R)-6-methyl-4-(10-phenyldecyl)-3,7-dioxabicyclo[4.1.0]heptan-2-one

Downstream raw materials:

methyl (2R,3R)-3-methyl-3-{(2RS)-2-methyl-12-phenyl-2-[(triethylsilyl)peroxy]dodecyl}oxirane-2-carboxylate

(2R,3S)-2-methyl-2-(2-methylene-12-phenyldodecyl)-3-vinyloxirane

(1S)-1-[(3R,5RS)-3,5-dimethyl-5-(10-phenyldecyl)-1,2-dioxolan-3-yl]prop-2-en-1-ol

triethyl((2-methyl-1-((2R,3S)-2-methyl-3-vinyloxiran-2-yl)-12-phenyldodecan-2-yl)peroxy)silane