(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

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Chemical Name:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt
CAS No.:1035040-52-8
Molecular Formula:C₂HF₃O₂*C₂₈H₃₅ClN₄O₃
Molecular Weight:625.088
Hs Code.:

Synonyms:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

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Chemical Property of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

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Technology Process of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

There total 5 articles about (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1035040-52-8
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

Guidance literature:

Reference yield: 58.0%

: 29006-02-8
4-methoxybutyric acid

: (R)-4-(4-chlorobenzyl)-2-((1-(2-(methylamino)ethyl)pyrrolidin-2-yl)methyl)phthalazin-1(2H)-one

: 76-05-1
trifluoroacetic acid

: 1035040-52-8
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

Guidance literature:: 4-methoxybutyric acid; (R)-4-(4-chlorobenzyl)-2-((1-(2-(methylamino)ethyl)pyrrolidin-2-yl)methyl)phthalazin-1(2H)-one; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

trifluoroacetic acid;
DOI:10.1021/acsmedchemlett.7b00112

Reference yield:

: 1035040-47-1
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide

: 1035040-52-8
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2: potassium carbonate / methanol; water / 7 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00112