methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

Base Information

Chemical Name:methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate
CAS No.:1350651-10-3
Molecular Formula:C₂₇H₃₁N₃O₄
Molecular Weight:461.561
Hs Code.:

Synonyms:methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

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Chemical Property of methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

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Technology Process of methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

There total 6 articles about methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 578-66-5
8-amino quinoline

: 1350651-06-7
di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

: 1350651-10-3
methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

: 1350651-08-9
methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

With oxalyl dichloride; In dichloromethane; at -30 - -15 ℃; for 0.5h;

8-amino quinoline; With pyridine; In dichloromethane; at -60 - -20 ℃; for 0.5h;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1350651-10-3
methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice

1.2: 1.17 h / 20 - 120 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

5.2: 0.5 h / -30 - -15 °C

5.3: 0.5 h / -60 - -20 °C

With potassium tert-butylate; ammonium formate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 278791-31-4
di-t-butyl 2-(4-nitrophenyl)malonate

: 1350651-10-3
methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.2: 0.5 h / -30 - -15 °C

4.3: 0.5 h / -60 - -20 °C

With ammonium formate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;