di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

Base Information

Chemical Name:di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate
CAS No.:1350651-06-7
Molecular Formula:C₂₇H₄₁NO₇
Molecular Weight:491.625
Hs Code.:

Synonyms:di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

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Chemical Property of di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

Chemical Property:

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Technology Process of di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

There total 5 articles about di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 3946-32-5
suberic acid monomethyl ester

: 1006950-22-6
di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

: 1350651-06-7
di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1350651-06-7
di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice

1.2: 1.17 h / 20 - 120 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With potassium tert-butylate; ammonium formate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1006899-48-4
di-tert-butyl 2-methyl-2-(4-nitrophenyl)malonate

: 1350651-06-7
di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane;