methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Base Information

Chemical Name:methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate
CAS No.:1350651-08-9
Molecular Formula:C₃₇H₃₇N₅O₅
Molecular Weight:631.731
Hs Code.:

Synonyms:methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

There total 6 articles about methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 578-66-5
8-amino quinoline

: 1350651-06-7
di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate

: 1350651-10-3
methyl 8-oxo-8-(4-(1-oxo-1-(quinolin-8-ylamino)propan-2-yl)phenylamino)octanoate

: 1350651-08-9
methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: di-tert-butyl 2-(4-(8-methoxy-8-oxooctanamido)phenyl)-2-methylmalonate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

With oxalyl dichloride; In dichloromethane; at -30 - -15 ℃; for 0.5h;

8-amino quinoline; With pyridine; In dichloromethane; at -60 - -20 ℃; for 0.5h;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1350651-08-9
methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice

1.2: 1.17 h / 20 - 120 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

5.2: 0.5 h / -30 - -15 °C

5.3: 0.5 h / -60 - -20 °C

With potassium tert-butylate; ammonium formate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 278791-31-4
di-t-butyl 2-(4-nitrophenyl)malonate

: 1350651-08-9
methyl 8-(4-(2-methyl-1,3-dioxo-1,3-bis(quinolin-8-ylamino)propan-2-yl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.2: 0.5 h / -30 - -15 °C

4.3: 0.5 h / -60 - -20 °C

With ammonium formate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;