2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

Base Information

Chemical Name:2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde
CAS No.:1288963-73-4
Molecular Formula:C₂₀H₁₆N₂O₃
Molecular Weight:332.359
Hs Code.:

Synonyms:2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

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Chemical Property of 2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

Chemical Property:

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Technology Process of 2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

There total 8 articles about 2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288963-04-1
2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

: 1288963-73-4
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

Guidance literature:: 2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile; With diisobutylaluminium hydride; In hexane; dichloromethane; at -60 - 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; water; In hexane; dichloromethane;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1288963-73-4
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3.1: N-Bromosuccinimide / dichloromethane / 0.03 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.75 h / 90 °C / Inert atmosphere

5.1: triethylamine / dimethyl sulfoxide / 120 - 150 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20.5 h / -50 - -20 °C

6.2: -78 °C

7.1: diisobutylaluminium hydride / dichloromethane; hexane / 16 h / -60 - 20 °C / Inert atmosphere

With methanol; N-Bromosuccinimide; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 99655-68-2
3-bromo-1-phenylsulfonyl indole

: 1288963-73-4
2-(3,5-dimethylisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3.1: N-Bromosuccinimide / dichloromethane / 0.03 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.75 h / 90 °C / Inert atmosphere

5.1: triethylamine / dimethyl sulfoxide / 120 - 150 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20.5 h / -50 - -20 °C

6.2: -78 °C

7.1: diisobutylaluminium hydride / dichloromethane; hexane / 16 h / -60 - 20 °C / Inert atmosphere

With methanol; N-Bromosuccinimide; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; hexane; dichloromethane; dimethyl sulfoxide;