2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

Base Information

Chemical Name:2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile
CAS No.:1288963-04-1
Molecular Formula:C₂₀H₁₅N₃O₂
Molecular Weight:329.358
Hs Code.:

Synonyms:2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

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Chemical Property of 2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

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Technology Process of 2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

There total 7 articles about 2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288963-69-8
2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-1H-indole-1-carbonitrile

: 1288963-04-1
2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

Guidance literature:: 2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-1H-indole-1-carbonitrile; With boron tribromide; In dichloromethane; at -50 - -20 ℃; for 20.5h;

With methanol; In dichloromethane; water; at -78 ℃;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1288963-04-1
2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3.1: N-Bromosuccinimide / dichloromethane / 0.03 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.75 h / 90 °C / Inert atmosphere

5.1: triethylamine / dimethyl sulfoxide / 120 - 150 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20.5 h / -50 - -20 °C

6.2: -78 °C

With methanol; N-Bromosuccinimide; boron tribromide; sodium hydrogencarbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 99655-68-2
3-bromo-1-phenylsulfonyl indole

: 1288963-04-1
2-(3,5-dimethyIisoxazol-4-yl)-3-(4-hydroxyphenyl)-1H-indole-1-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 85 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux

3.1: N-Bromosuccinimide / dichloromethane / 0.03 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.75 h / 90 °C / Inert atmosphere

5.1: triethylamine / dimethyl sulfoxide / 120 - 150 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20.5 h / -50 - -20 °C

6.2: -78 °C

With methanol; N-Bromosuccinimide; boron tribromide; sodium hydrogencarbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;