ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

Base Information

Chemical Name:ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate
CAS No.:1616458-56-0
Molecular Formula:C₃₄H₃₈ClN₃O₆
Molecular Weight:620.145
Hs Code.:

Synonyms:ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

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Chemical Property of ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

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Technology Process of ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

There total 6 articles about ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 35019-78-4
ethyl 4-amino-5-chloro-2-methoxybenzoate

: 4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoic acid hydrochloride

: 1616458-56-0
ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

Guidance literature:: 4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoic acid hydrochloride; With thionyl chloride; at 20 ℃; for 1h; Inert atmosphere;

ethyl 4-amino-5-chloro-2-methoxybenzoate; With triethylamine; In chloroform; at 20 ℃;

Reference yield:

: 64085-52-5
5-bromo-2-iodo-aniline

: 1616458-56-0
ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2.1: 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; palladium diacetate / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: triethylamine / toluene / 4 h / 0 - 20 °C

3.2: 24 h / 80 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.1: thionyl chloride / 1 h / 20 °C / Inert atmosphere

5.2: 20 °C

With thionyl chloride; lithium hydroxide monohydrate; 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; water; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; 2.1: |Heck Reaction;

Reference yield:

: 98-80-6
phenylboronic acid

: 1616458-56-0
ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2.1: 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; palladium diacetate / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: triethylamine / toluene / 4 h / 0 - 20 °C

3.2: 24 h / 80 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.1: thionyl chloride / 1 h / 20 °C / Inert atmosphere

5.2: 20 °C

With thionyl chloride; lithium hydroxide monohydrate; 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; water; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; 2.1: |Heck Reaction;