1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

Base Information

Chemical Name:1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate
CAS No.:1616458-57-1
Molecular Formula:C₃₂H₃₆ClN₃O₅
Molecular Weight:578.108
Hs Code.:

Synonyms:1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

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Chemical Property of 1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

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Technology Process of 1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

There total 7 articles about 1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1616458-56-0
ethyl 4-{[4-(2-{[(1-azabicyclo[2.2.2]oct-4-yloxy)carbonyl]amino}biphenyl-4-yl)butanoyl]amino}-5-chloro-2-methoxybenzoate

: 1616458-57-1
1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 64085-52-5
5-bromo-2-iodo-aniline

: 1616458-57-1
1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2.1: 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; palladium diacetate / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: triethylamine / toluene / 4 h / 0 - 20 °C

3.2: 24 h / 80 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.1: thionyl chloride / 1 h / 20 °C / Inert atmosphere

5.2: 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; lithium hydroxide monohydrate; 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; water; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; 2.1: |Heck Reaction;

Reference yield:

: 98-80-6
phenylboronic acid

: 1616458-57-1
1-azabicyclo[2.2.2]oct-4-yl [4-(4-{[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]-amino}-4-oxobutyl)biphenyl-2-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2.1: 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; palladium diacetate / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: triethylamine / toluene / 4 h / 0 - 20 °C

3.2: 24 h / 80 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.1: thionyl chloride / 1 h / 20 °C / Inert atmosphere

5.2: 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; lithium hydroxide monohydrate; 2-dicyclohexylamino-2',6'-dimethoxy-1,1'-biphenyl; water; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; 2.1: |Heck Reaction;