3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Base Information

Chemical Name:3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide
CAS No.:1282521-38-3
Molecular Formula:C₂₅H₂₉N₃O₅
Molecular Weight:451.522
Hs Code.:

Synonyms:3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

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Chemical Property of 3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

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Technology Process of 3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

There total 8 articles about 3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.4%

: 1282521-42-9
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1282521-38-3
3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Guidance literature:: With potassium chloride; 18-crown-6 ether; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-38-3
3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C

8.1: potassium chloride / 18-crown-6 ether / dichloromethane / 20 h / 20 °C

With methanol; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; potassium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1282520-98-2
dimethyl 5-hydroxy isophthalate

: 1282521-38-3
3-[trans-2-(2,3-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

2: 3 h / 160 °C

3: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C

5: potassium chloride / 18-crown-6 ether / dichloromethane / 20 h / 20 °C

With tribromo phosphate; potassium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;