3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

Base Information

Chemical Name:3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide
CAS No.:1282521-42-9
Molecular Formula:C₂₀H₃₀N₃O₆P
Molecular Weight:439.448
Hs Code.:

Synonyms:3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

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Chemical Property of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

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Technology Process of 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

There total 11 articles about 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1417647-99-4
C₁₆H₂₀BrN₃O₃

: 122-52-1
triethyl phosphite

: 1282521-42-9
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

Guidance literature:: Reflux;
DOI:10.1016/j.bmcl.2012.11.018

Reference yield: 41.8%

: 1282521-11-2
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1904-31-0
methyl-1 amino-3 pyrazole

: 1282521-42-9
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

Guidance literature:: 3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid; methyl-1 amino-3 pyrazole; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-42-9
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benz amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 12 h / 20 °C

With methanol; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane;