(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

Base Information

Chemical Name:(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester
CAS No.:475148-09-5
Molecular Formula:C₄₉H₆₀N₂O₉
Molecular Weight:821.023
Hs Code.:

(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

Synonyms:(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

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Chemical Property of (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

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Technology Process of (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

There total 2 articles about (2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 475148-13-1
((1R,3R)-1-Benzyl-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-carbamic acid tert-butyl ester

: 475148-08-4
(R)-2-((R)-3-Benzyl-4-oxo-oxetan-2-yl)-3-phenyl-propionic acid allyl ester

: 475148-09-5
(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

Guidance literature:: ((1R,3R)-1-Benzyl-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-carbamic acid tert-butyl ester; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

(R)-2-((R)-3-Benzyl-4-oxo-oxetan-2-yl)-3-phenyl-propionic acid allyl ester; In tetrahydrofuran; diethyl ether; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(02)00204-1

Reference yield:

: 184377-91-1
(2R,4R)-2,4-dibenzyl-3-hydroxypentanedioic acid

: 475148-09-5
(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 15 h / 20 °C

2.1: i-PrMgCl / tetrahydrofuran; diethyl ether / 1 h / 0 °C

2.2: 50 percent / tetrahydrofuran; diethyl ether / 24 h / 20 °C

With dmap; isopropylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(02)00204-1

Reference yield: 59.0%

: 475148-09-5
(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid allyl ester (R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl ester

: 475148-14-2
(2R,4R)-2,4-Dibenzyl-3-hydroxy-pentanedioic acid mono-[(R)-2-tert-butoxycarbonylamino-1-((R)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-3-phenyl-propyl] ester

Guidance literature:: With formic acid; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 40h;
DOI:10.1016/S0040-4020(02)00204-1