1-(1-chloro-2,2,2-trifluoro-ethyl)-3-(trifluoromethyl)benzene

Base Information

• Chemical Name: 1-(1-chloro-2,2,2-trifluoro-ethyl)-3-(trifluoromethyl)benzene
• CAS No.: 2925-57-7
• Molecular Formula: C9H5 Cl F6
• Molecular Weight: 0
• Hs Code.: 2903999090
• Mol file: 2925-57-7.mol

Synonyms:Toluene,m-(1-chloro-2,2,2-trifluoroethyl)-a,a,a-trifluoro- (6CI,8CI); NSC 55873

Chemical Property of 1-(1-chloro-2,2,2-trifluoro-ethyl)-3-(trifluoromethyl)benzene

Chemical Property:

• Vapor Pressure: 2.9mmHg at 25°C
• Boiling Point: 161.9°C at 760 mmHg
• Flash Point: 68.7°C
• PSA: 0.00000
• Density: 1.424g/cm³
• LogP: 4.54760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-chloro-2,2,2-trifluoro-ethyl)-3-(trifluoromethyl)benzene

There total 5 articles about 1-(1-chloro-2,2,2-trifluoro-ethyl)-3-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

α-trifluoromethyl-m-trifluoromethylbenzyl alcohol (721-36-8) → 1-chloro-1-(3-trifluoromethylphenyl)-2,2,2-trifluoroethane (2925-57-7)

Guidance literature:

With pyridine; thionyl chloride; N,N-dimethyl-formamide; Heating;

DOI:10.1016/j.jfluchem.2005.05.005

Reference yield:

2,2,2-trifluoro-3'-(trifluoromethyl)acetophenone (721-37-9) → 1-chloro-1-(3-trifluoromethylphenyl)-2,2,2-trifluoroethane (2925-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄; aqueous dioxane

2: pyridine; thionyl chloride / 150 °C

With 1,4-dioxane; pyridine; sodium tetrahydroborate; thionyl chloride;

DOI:10.1021/jo01359a613

Reference yield:

3-(trifluoromethyl)phenylmagnesium bromide (402-26-6) → 1-chloro-1-(3-trifluoromethylphenyl)-2,2,2-trifluoroethane (2925-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: NaBH₄; aqueous dioxane

3: pyridine; thionyl chloride / 150 °C

With 1,4-dioxane; pyridine; sodium tetrahydroborate; thionyl chloride; diethyl ether;

DOI:10.1021/jo01359a613

upstream raw materials:

α-trifluoromethyl-m-trifluoromethylbenzyl alcohol

1-chloro-2,2,2-trifluoroethylbenzene

C₉H₅F₆⁽¹⁺⁾

1,1,1-Trifluor-2-(m-trifluormethylphenyl)ethan

Downstream raw materials:

1,1,1-Trifluor-2-(m-trifluormethylphenyl)ethan