methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

Base Information

Chemical Name:methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate
CAS No.:50415-79-7
Molecular Formula:C₁₆H₁₃ClO₂
Molecular Weight:272.731
Hs Code.:

Synonyms:methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

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Chemical Property of methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

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Technology Process of methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

There total 13 articles about methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1188274-68-1
methyl (E)-2-(4-chlorophenyl)-3-(p-toluenesulfonyloxy)prop-2-enoate

: 98-80-6
phenylboronic acid

: 50415-79-7
methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

Guidance literature:: With palladium diacetate; sodium carbonate; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 150 - 155 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol9013359

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1657-63-2
(E)-2,3-bis(4-chlorophenyl)-2-propenoic acid

: 50415-79-7
methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

: C₁₆H₁₅ClO₂

: C₁₆H₁₅ClO₂

: C₁₆H₁₄Cl₂O₂

: C₁₆H₁₄Cl₂O₂

Guidance literature:: (E)-2,3-bis(4-chlorophenyl)-2-propenoic acid; With palladium/alumina; hydrogen; cinchonidine; In water; N,N-dimethyl-formamide; at 21.84 ℃; for 6h; under 750.075 Torr;

diazomethane; In diethyl ether; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.molcata.2010.09.013

Reference yield:

: 37542-28-2
methyl (p-chlorphenyl)glyoxylate

: 100-39-0
benzyl bromide

: 50415-79-7
methyl (E)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

: 151358-36-0
methyl (Z)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

Guidance literature:: methyl (p-chlorphenyl)glyoxylate; benzyl bromide; With Hexamethylphosphorous triamide; In acetonitrile; at -40 - 20 ℃; for 1.5h; Inert atmosphere;

With water; In acetonitrile; at 60 ℃; for 2h; Overall yield = 85 %; Overall yield = 232 mg; chemoselective reaction;
DOI:10.1021/acs.orglett.5b01784