4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate
CAS No.:1423007-54-8
Molecular Formula:C₂₇H₂₁ClF₄N₂O₇S₂
Molecular Weight:661.052
Hs Code.:

4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

Synonyms:4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

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Chemical Property of 4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

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Technology Process of 4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

There total 16 articles about 4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1423007-53-7
2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

: 1423007-54-8
4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1423007-52-6
6-{N-[4-(benzyloxy)-3-fluorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-1-benzofuran-3-carboxamide

: 1423007-54-8
4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 20 °C / 760.05 Torr

2: pyridine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 1331943-23-7
5-cyclopropyl-2-(4-chlorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid

: 1423007-54-8
4-{N-[2-(4-chlorophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-fluorophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 2 h

2.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 20 °C / 760.05 Torr

4.1: pyridine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;