2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide
CAS No.:1423007-53-7
Molecular Formula:C₂₆H₂₂ClFN₂O₅S
Molecular Weight:528.988
Hs Code.:

Synonyms:2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

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Chemical Property of 2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

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Technology Process of 2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

There total 15 articles about 2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423007-52-6
6-{N-[4-(benzyloxy)-3-fluorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-1-benzofuran-3-carboxamide

: 1423007-53-7
2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 2h; under 760.051 Torr;

Reference yield:

: 1331943-23-7
5-cyclopropyl-2-(4-chlorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid

: 1423007-53-7
2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 2 h

2.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1331943-24-8
2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1423007-53-7
2-(4-chlorophenyl)-5-cyclopropyl-6-[N-(3-fluoro-4-hydroxyphenyl)methanesulfonamido]-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; In ethanol; dichloromethane; ethyl acetate;