6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

Base Information

Chemical Name:6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl
CAS No.:325685-61-8
Molecular Formula:C₂₅H₂₄N₄OS
Molecular Weight:428.558
Hs Code.:

Synonyms:6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

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Chemical Property of 6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

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Technology Process of 6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

There total 5 articles about 6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 325685-61-8
6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOMe / methanol; ethanol / 21 h / Heating

2.1: 29.0 g / POCl₃ / 3 h / Heating

3.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

3.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

4.1: 9.47 g / aq. HCl / acetone / 20 °C

5.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

5.2: tetrahydrofuran / 20 h / 35 °C

5.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

With hydrogenchloride; sodium methylate; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetone; 3.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 127958-19-4
4-(methoxymethyl)-2-phenylpyrimidine

: 325685-61-8
6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

Guidance literature:: Multi-step reaction with 4 steps

1.1: 29.0 g / POCl₃ / 3 h / Heating

2.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

2.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

3.1: 9.47 g / aq. HCl / acetone / 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: tetrahydrofuran / 20 h / 35 °C

4.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

With hydrogenchloride; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; 2.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 1670-14-0
benzamidine monohydrochloride

: 325685-61-8
6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOMe / methanol; ethanol / 21 h / Heating

2.1: 29.0 g / POCl₃ / 3 h / Heating

3.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

3.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

4.1: 9.47 g / aq. HCl / acetone / 20 °C

5.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

5.2: tetrahydrofuran / 20 h / 35 °C

5.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

With hydrogenchloride; sodium methylate; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetone; 3.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M