DO₂A-GA

Base Information

• Chemical Name: DO₂A-GA
• CAS No.: 1418543-75-5
• Molecular Formula: C₃₆H₆₀N₄O₈
• Molecular Weight: 676.894
• Mol file: 1418543-75-5.mol

Synonyms:DO₂A-GA

Chemical Property of DO₂A-GA

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DO₂A-GA

There total 1 articles about DO₂A-GA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(2S)-2-bromopentanedioic acid 1-(1,1-dimethylethyl)-5-(phenylmethyl) ester (873201-11-7) + (7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester (162148-48-3) → DO2A-GA (1418543-75-5)

Guidance literature:

With sodium carbonate; In acetonitrile; at 60 ℃;

DOI:10.1021/cn400175m

Reference yield:

(S)-tert-butyl 6-(benzyloxycarbonylamino)-2-bromohexanoate (873201-29-7) + DO2A-GA (1418543-75-5) → C54H85N5O12

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

DOI:10.1021/cn400175m

Reference yield:

DO2A-GA (1418543-75-5) + 2-bromo-N-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methyl)acetamide (1497422-15-7) → C51H70N6O11 (1497422-23-7)

Guidance literature:

With base; In acetonitrile; at 80 ℃;

DOI:10.1021/cn400175m

upstream raw materials:

(2S)-2-bromopentanedioic acid 1-(1,1-dimethylethyl)-5-(phenylmethyl) ester

(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

Downstream raw materials:

(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)-ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

(R)-di-tert-butyl 2,2′-(4-(1-tert-butoxy-5-(2-(3-(6-(6-methylpyridin-2-ylcarbamoyl)pyridin-3-yl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)-methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)-diacetate

(R)-2,2′-(4-(1-carboxy-4-(2-(3-((2-methylthiazol-4-yl)ethynyl)-phenoxy)ethylamino)-4-oxobutyl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

(R)-2,2′-(4-(1-carboxy-4-(2-(3-(6-(6-methylpyridin-2-ylcarbamoyl)pyridin-3-yl)phenoxy)ethylamino)-4-oxobutyl)-10-(2-oxo-2-((5-oxo-5H-chromeno[2,3-b]pyridin-2-yl)methylamino)-ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid