4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 544694-62-4
• Molecular Formula: C₂₉H₃₈N₆O₅S
• Molecular Weight: 582.724
• Mol file: 544694-62-4.mol

Synonyms:4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[4-({1-[3-(N-hydroxycarbamimidoyl)-phenyl]-5-methyl-1H-pyrazol-3-ylmethyl}-methanesulfonyl-amino)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester → 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (544694-62-4)

Guidance literature:

4-[4-({1-[3-(N-hydroxycarbamimidoyl)-phenyl]-5-methyl-1H-pyrazol-3-ylmethyl}-methanesulfonyl-amino)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester; With acetic anhydride; acetic acid;

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (544694-62-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: pyridine

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(4-{[1-(3-carbamimidoyl-phenyl)-5-methyl-1H-pyrazol-3-ylmethyl]-methanesulfonyl-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (544694-62-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: pyridine

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

upstream raw materials:

4-Fluoronitrobenzene

ethyl 5-methyl-2H-pyrazole-3-carboxylate

(3‐cyanophenyl)boronic acid

t-butyl 4-hydroxy piperidine-1-carboxylate