7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Base Information

Chemical Name:7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
CAS No.:1439395-75-1
Molecular Formula:C₂₂H₁₉N₅O₂
Molecular Weight:385.425
Hs Code.:

Synonyms:7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

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Chemical Property of 7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

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Technology Process of 7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

There total 6 articles about 7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1439395-72-8
7-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

: 1439395-75-1
7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1439395-38-6
tert-butyl 1-(4-(6-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-75-1
7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 80 °C / Inert atmosphere

2: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

3: 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 14 h / 80 °C / 2585.81 Torr / Inert atmosphere

4: lithium hydroxide; water / methanol / 2 h / 30 °C / Inert atmosphere

5: hydrogenchloride / ethyl acetate / 3 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; potassium fluoride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; palladium diacetate; caesium carbonate; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1439395-68-2
7-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid methyl ester

: 1439395-75-1
7-[4-(1-amino-cyclobutyl)-phenyl]-6-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol / 2 h / 30 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 3 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; lithium hydroxide; In methanol; ethyl acetate;