6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide

Base Information

• Chemical Name: 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide
• CAS No.: 912806-31-6
• Molecular Formula: C₂₄H₂₆BrNO₇
• Molecular Weight: 520.377
• Mol file: 912806-31-6.mol

Synonyms:6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide

Chemical Property of 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide

There total 5 articles about 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amine (912806-27-0) + 6-bromohexanoyl chloride (22809-37-6) → 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide (912806-31-6)

Guidance literature:

N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amine; With sodium hydride; In dibutyl ether; at 20 ℃; for 2h;

6-bromohexanoyl chloride; In dibutyl ether; for 4h; Heating;

DOI:10.1021/jm060468y

Reference yield:

N-(4-ethoxycarbonylphenyl)-N-(3,4-di(ethoxycarbonyl)phenyl)acetamide (912806-24-7) → 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide (912806-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 81 percent / methanol / 1.5 h / Heating

2.1: sodium hydride / dibutyl ether / 2 h / 20 °C

2.2: 85 percent / dibutyl ether / 4 h / Heating

With sodium hydride; In methanol; dibutyl ether;

DOI:10.1021/jm060468y

Reference yield:

4-nitrophthalic acid diethyl ester (2050-19-3) → 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide (912806-31-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 99 percent / FeCl₂; NaBH₄ / ethanol / 3 h / Heating

2.1: 87 percent / acetic acid / 1 h / Heating

3.1: 44 percent / Cu; copper (I) iodide; potassium carbonate / dibutyl ether / 96 h / Heating

4.1: 81 percent / methanol / 1.5 h / Heating

5.1: sodium hydride / dibutyl ether / 2 h / 20 °C

5.2: 85 percent / dibutyl ether / 4 h / Heating

With sodium tetrahydroborate; copper(l) iodide; copper; sodium hydride; potassium carbonate; acetic acid; iron(II) chloride; In methanol; ethanol; dibutyl ether;

DOI:10.1021/jm060468y

upstream raw materials:

N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amine

6-bromohexanoyl chloride

N-(4-ethoxycarbonylphenyl)-N-(3,4-di(ethoxycarbonyl)phenyl)acetamide

4-nitrophthalic acid diethyl ester

Downstream raw materials:

4-[[6-(3,5-bis-decyloxy-phenoxy)-hexanoyl]-(4-methoxycarbonyl-phenyl)-amino]-phthalic acid dimethyl ester