2050-19-3

Usage

Uses

Used in Organic Synthesis:
Diethyl 4-nitrobenzene-1,2-dicarboxylate is used as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions, facilitating the formation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, diethyl 4-nitrobenzene-1,2-dicarboxylate is used as a building block for the preparation of various drugs. Its structural properties make it a valuable component in the synthesis of medicinal compounds.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, diethyl 4-nitrobenzene-1,2-dicarboxylate is employed as a precursor in the development of agrochemicals, contributing to the production of substances used in agriculture for pest control and crop protection.
Safety Considerations:
Due to its potential to react violently with strong oxidizing agents, diethyl 4-nitrobenzene-1,2-dicarboxylate requires careful handling and is typically used under controlled conditions to ensure safety in laboratory settings. Additionally, it is important to take precautions to avoid skin, eye, and respiratory system irritation during its use.

Upstream product

• 64-17-5 ethanol 
• 610-27-5 4-nitrophthalic acid 
• 5466-84-2 4-nitrophthalic anhydride 
• 84-66-2 Diethyl phthalate 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 105969-98-0 2-hydroxy-6-nitro-1H-isoindole-1,3-dione 
• 22572-84-5 diethyl 4-aminophthalate 
• 943749-63-1 4-bromo-2-(carboxymethyl)benzoic acid 
• 67193-51-5 4-iodophthalic acid diethyl ester 
• 38568-41-1 diethyl 4-bromophthalate 
• 149967-20-4 4-acetylaminophthalic acid diethyl ester 
• 875211-06-6 4-[[6-(3,5-bis-decyloxy-phenoxy)-hexanoyl]-(4-methoxycarbonyl-phenyl)-amino]-phthalic acid dimethyl ester 
• 912806-31-6 6-bromohexanoic acid N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amide 
• 912806-24-7 N-(4-ethoxycarbonylphenyl)-N-(3,4-di(ethoxycarbonyl)phenyl)acetamide 
• 912806-27-0 N-(4-methoxycarbonylphenyl)-N-(3,4-di(methoxycarbonyl)phenyl)amine 
• 22162-19-2 (4-nitro-1,2-phenylene)dimethanol 
• 3682-14-2 isoluminol 
• 105969-95-7 6-(N-ethylamino)-2-(p-toluenesulfonyloxy)-1H-isoindole-1,3-dione 

Relevant academic research and scientific papers

Volatility of some aromatic nitrosubstituted plasticizers for polymers

Nine derivatives of nitrophthalic acids and nitrophenols were synthesized as potential plasticizers for polymers and structurally characterized by 1H NMR and elemental analysis. The time dependences of the weight loss for the nitro derivatives

A color filter and an azo compound dye for containing the same

Provided is a yellow coloring matter which exhibits excellent solubility in solvents that are to be used in forming the pixels of a color filter. This azo compound is represented by formula (1) [wherein R1s are each independently a straight, branched or c

Aerobic oxidation of cyclohexane using N-hydroxyphthalimide bearing fluoroalkyl chains

The N-hydroxyphthalimide derivatives, F15-and F 17-NHPI, bearing a long fluorinated alkyl chain, were prepared and their catalytic performances were compared with that of the parent compound, N-hydroxyphthalimide (NHPI). The oxidation of cyclohexane under 10 atm of air in the presence of fluorinated F15-or F17-NHPI, cobalt diacetate [Co(OAc)2], and manganese diacetate [Mn(OAc)2] without any solvent at 100°C afforded a mixture of cyclohexanol and cyclohexanone (K/A oil) as major products along with a small amount of adipic acid. It was found that F15-and F17-NHPI exhibit higher catalytic activity than NHPI for the oxidation of cyclohexane without a solvent. However, for the oxidation in acetic acid all of these catalysts afforded adipic acid as a major product in good yield and the catalytic activity of NHPI in acetic acid was almost the same as those of F15-and F 17-NHPI. The oxidation by F15-and F17-NHPI catalysts in trifluorotoluene afforded K/A oil in high selectivity with little formation of adipic acid, while NHPI was a poor catalyst under these conditions, forming K/A oil as well as adipic acid in very low yields. The oxidation in trifluorotoluene by F15-and F17-NHPI catalysts was considerably accelerated by the addition of a small amount of zirconium(IV) acetylacetonate [Zr(acac)4] to the present catalytic system to afford selectively K/A oil, but no such effect was observed in the NHPI-catalyzed oxidation in trifluorotoluene.

Immunoassay for phthalic acid esters

The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a carrier protein and a phthalic acid ester derivative represented by the formula wherein R1and R2may be the same or different and are hydrogen, alkyl, cycloalkyl or phenylalkyl, with the proviso that both of R1and R2are not hydrogen; m is an integer from 1 to 5; and Y is amino or carboxyl.

Nonacid nitration of benzenedicarboxylic and naphthalenecarboxylic acid esters

When treated with nitrogen dioxide in the presence of ozone and a catalytic amount of iron(III) chloride in inert organic solvent at -10 to +5 °C, benzenedicarboxylic acid diesters 1, 4, and 6 underwent smooth nitration to give the corresponding mononitro derivatives 2/3, 5, and 7, respectively, in good yield (kyodai nitration). Naphthalenecarboxylic acid esters 8 and 11 and naphthalene-1,8-dicarboxylic acid diester 16 were similarly nitrated in the absence of catalyst to give the expected nitro compounds 9/10, 12-15, and 17-22, respectively. Different from conventional nitration based on the combined use of concentrated nitric and sulfuric acids, no hydrolytic cleavage of the ester function was observed under these conditions. The isomer distribution has been determined for the nitration of naphthalenecarboxylic acid esters 8, 11, and 16, and spectral data were collected for less common nitro derivatives. A unique changeover of the orientation mode observed in the kyodai nitration of diester 16, from the initial exclusive meta to the final meta/para, has been discussed in terms of the competition between the electrophilic substitution process involving the nitronium ion (NO2+) and the addition-elimination sequence involving the nitrogen trioxide radical (NO3).

Design, Synthesis and Cytotoxicity of 2-Hydroxy-1(H)-isoindole-1,3-dione (HISD) Derivatives Against CEM/O Human Leukemia Cells in vitro

2-Hydroxy-1(H)-isoindole-1,3-dione derivatives (HISDs) possess a hydroxamic acid moiety which is built into an isoindoledione ring. Seven new compounds have been synthesized and tested for cytotoxicity against CEM human leukemia cell lines. Three active c

Pyrophtalones VII. Synthese et activite anti-inflammatoire de (pyridinyl-4)-2 indanediones-1,3 substituees sur le noyau benzenique et/ou sur l'heterocycle

Pyrophthalones VII.Synthesis and anti-inflammatory activity of 2-(4-pyridinyl)indane-1,3-diones diversely substituted on the benzene ring.Access routes to 2-(1,4-dihydro 4-pyridinylidene) indane-1,3-diones diversely substituted on the benzene ring are studied.The regiospecific attack of these β diketoenamines by alkyl iodides leads to N-substituted compounds.These derivatives may be obtained by any of three possible methods: (1) condensation of 4-methyl pyridine with ethyl phthalates in the absence of catalyst; (2) oxidative condensation of N-alkyl-pyridinium bromides with indane-1,3-diones; (3) aminolysis of 2-(4-4H-pyranylidene) indane-1,3-diones.Pharmacomodulation by the introduction of oxygen or sulfur containing functions (ether, thioether, alcohol, ketone, acid, ester, amide) on the nitrogen of the basic molecule is not very fruitful; only the acetic derivative 19 manifests marked antiinflammatory activity unaccompanied by anti-coagulant action.The presence of chloro, nitro or methoxyl groups on 5 after N-substitution by ethyl or piperidinylethyl groups appears to be more favorable.The most active compound 57 decreases prostaglandin production and leukocyte migration without affecting either cyclooxygenase or 5-lipoxygenase.Its interference, direct or indirect, with phospholipasic A2 activity may be envisaged in particular.Keywords - 2-(4-pyridinyl)indane-1,3-diones / heterocyclic β diketoenamines / partition coefficient / anti-inflammatory activity / mechanism of action