1H-Indole, 4-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1-(methylsulfonyl)-, mono(trifluoroacetate)

Base Information

Chemical Name:1H-Indole, 4-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1-(methylsulfonyl)-, mono(trifluoroacetate)
CAS No.:847990-59-4
Molecular Formula:C34H32ClF3N2O3S.C2HF3O2
Molecular Weight:755.178
Hs Code.:

1H-Indole,
4-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino
]propoxy]-1-(methylsulfonyl)-, mono(trifluoroacetate)

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole, 4-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1-(methylsulfonyl)-, mono(trifluoroacetate)

Chemical Property:

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Technology Process of 1H-Indole, 4-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1-(methylsulfonyl)-, mono(trifluoroacetate)

There total 3 articles about 1H-Indole, 4-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino ]propoxy]-1-(methylsulfonyl)-, mono(trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 847990-40-3
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

: 124-63-0
methanesulfonyl chloride

: 76-05-1
trifluoroacetic acid

: 847990-59-4
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(3-(1-methanesulfonyl-1H-indol-4-yl)oxy)-propyl]-amine trifluoroacetate

Guidance literature:: (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine; methanesulfonyl chloride; With sodium hydride; In N,N-dimethyl-formamide;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 847990-59-4
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(3-(1-methanesulfonyl-1H-indol-4-yl)oxy)-propyl]-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

2: potassium carbonate / acetonitrile / Heating / reflux

3: potassium carbonate / acetonitrile / 90 °C

4: sodium hydride / N,N-dimethyl-formamide

With sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 405911-35-5
N-(2,2-diphenylethyl)-N-(2-chloro-trifluoromethylbenzyl)amine

: 847990-59-4
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(3-(1-methanesulfonyl-1H-indol-4-yl)oxy)-propyl]-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / Heating / reflux

2: potassium carbonate / acetonitrile / 90 °C

3: sodium hydride / N,N-dimethyl-formamide

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;