Technology Process of (R)-3-[N(1)-benzylpiperidin-2-yl]propanal
There total 12 articles about (R)-3-[N(1)-benzylpiperidin-2-yl]propanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(methoxymethyl)triphenylphosphonium chloride;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 0.5h;
(R)-2-[N(1)-benzylpiperidin-2-yl]ethanal;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
With
formic acid;
In
dichloromethane;
at 20 ℃;
for 16h;
DOI:10.1016/j.tet.2011.09.038
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: 1H-imidazole; iodine; triphenylphosphine / toluene; acetonitrile / 16 h / 65 °C
3.1: silver tetrafluoroborate / 16 h / 80 °C
4.1: diisobutylaluminium hydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C
5.2: -78 - 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 20 °C
6.2: 16 h / 20 °C
6.3: 16 h / 20 °C
With
1H-imidazole; silver tetrafluoroborate; n-butyllithium; oxalyl dichloride; potassium tert-butylate; iodine; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane; toluene; acetonitrile;
5.1: Swern oxidation / 5.2: Swern oxidation / 6.1: Wittig reaction / 6.2: Wittig reaction;
DOI:10.1016/j.tet.2011.09.038
