1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

Base Information

Chemical Name:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril
CAS No.:374694-98-1
Molecular Formula:C₃₃H₂₉Cl₂NO₆Si
Molecular Weight:634.588
Hs Code.:

Synonyms:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

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Chemical Property of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

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Technology Process of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

There total 4 articles about 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 374694-90-3
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

: 1066-54-2
trimethylsilylacetylene

: 374694-98-1
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 50 - 60 ℃; for 5h;
DOI:10.1081/NCN-100105246

Reference yield:

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 374694-98-1
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

3.1: 78 percent / CuI; Et₃N / (Ph₃P)2PdCl₂ / 5 h / 50 - 60 °C

With copper(l) iodide; N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; acetonitrile;
DOI:10.1081/NCN-100105246

Reference yield:

: 491-30-5
1-isoquinolone

: 374694-98-1
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-trimethylsilylethynyl)isocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

3.1: 78 percent / CuI; Et₃N / (Ph₃P)2PdCl₂ / 5 h / 50 - 60 °C

With copper(l) iodide; N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; acetonitrile;
DOI:10.1081/NCN-100105246