3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Base Information

Chemical Name:3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid
CAS No.:1025763-33-0
Molecular Formula:C₂₅H₂₂FNO₂
Molecular Weight:387.454
Hs Code.:

Synonyms:3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

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Chemical Property of 3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Chemical Property:

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Technology Process of 3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

There total 5 articles about 3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1025763-31-8
3-(1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

: 460-00-4
1-Bromo-4-fluorobenzene

: 1025763-33-0
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Guidance literature:: With potassium carbonate; copper(l) iodide; tetra-(n-butyl)ammonium iodide; trans-1,2-cyclohexanediamine; In 1,4-dioxane; at 110 ℃; for 24h;

Reference yield:

: 1025763-25-0
5-formyl-N,N-dimethyl-1H-indole-1-carboxamide

: 1025763-33-0
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran

2: boron trifluoride diethyl etherate / dichloromethane

3: sodium hydroxide / methanol; dimethyl sulfoxide

4: copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane; potassium carbonate; tetra-(n-butyl)ammonium iodide / 1,4-dioxane

With copper(l) iodide; boron trifluoride diethyl etherate; (1R,2R)-1,2-diaminocyclohexane; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2013.08.049

Reference yield:

: 1025763-27-2
5-(hydroxy(phenyl)methyl)-N,N-dimethyl-1H-indole-1-carboxamide

: 1025763-33-0
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / dichloromethane

2: sodium hydroxide / methanol; dimethyl sulfoxide

3: copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane; potassium carbonate; tetra-(n-butyl)ammonium iodide / 1,4-dioxane

With copper(l) iodide; boron trifluoride diethyl etherate; (1R,2R)-1,2-diaminocyclohexane; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2013.08.049