3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

Base Information

Chemical Name:3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide
CAS No.:1025761-31-2
Molecular Formula:C₂₈H₂₄FN₃OS
Molecular Weight:469.582
Hs Code.:

Synonyms:3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

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Chemical Property of 3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

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Technology Process of 3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

There total 6 articles about 3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 96-50-4
2-thiazolylamine

: 1025763-33-0
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

: 1025761-31-2
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 5.08333h;

Reference yield:

: 1025763-25-0
5-formyl-N,N-dimethyl-1H-indole-1-carboxamide

: 1025761-31-2
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: boron trifluoride diethyl etherate / dichloromethane

3: sodium hydroxide / methanol; dimethyl sulfoxide

4: copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane; potassium carbonate; tetra-(n-butyl)ammonium iodide / 1,4-dioxane

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With copper(l) iodide; boron trifluoride diethyl etherate; (1R,2R)-1,2-diaminocyclohexane; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.08.049

Reference yield:

: 1025763-27-2
5-(hydroxy(phenyl)methyl)-N,N-dimethyl-1H-indole-1-carboxamide

: 1025761-31-2
3-(1-(4-fluorophenyl)-1H-indol-5-yl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate / dichloromethane

2: sodium hydroxide / methanol; dimethyl sulfoxide

3: copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane; potassium carbonate; tetra-(n-butyl)ammonium iodide / 1,4-dioxane

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With copper(l) iodide; boron trifluoride diethyl etherate; (1R,2R)-1,2-diaminocyclohexane; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.08.049