(3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

Base Information

Chemical Name:(3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone
CAS No.:877438-36-3
Molecular Formula:C₃₁H₅₀O₅S₂Si
Molecular Weight:594.952
Hs Code.:

(3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

Synonyms:(3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

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Chemical Property of (3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

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Technology Process of (3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

There total 2 articles about (3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 877438-30-7
2-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)-1,3-dithiane

: 112968-75-9,122079-41-8,122079-45-2,135041-07-5,77934-87-3
(5R)-(L-menthyloxy)-2(5H)-furanone

: 877438-36-3
(3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

Guidance literature:: 2-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)-1,3-dithiane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(5R)-(L-menthyloxy)-2(5H)-furanone; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Further stages.;
DOI:10.1039/b513303c

Reference yield:

: 69404-94-0
O-tert-butyldimethylsilylvanillin

: 877438-36-3
(3R,4R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxy-3-methoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / MgBr₂ / diethyl ether / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 88 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 2 h / -78 °C

With n-butyllithium; magnesium bromide; In tetrahydrofuran; diethyl ether; hexane; 2.2: Michael addition;
DOI:10.1039/b513303c