1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol

Base Information

• Chemical Name: 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol
• CAS No.: 863498-88-8
• Molecular Formula: C₁₈H₂₀O
• Molecular Weight: 252.356
• Mol file: 863498-88-8.mol

Synonyms:1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol

Chemical Property of 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol

There total 3 articles about 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(3'-phenylprop-1'-ynyl)cyclohex-1-ene-1-carbaldehyde (863498-62-8) + vinyl magnesium bromide (1826-67-1) → 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol (863498-88-8)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1002/ejoc.200400922

Reference yield:

propargyl benzene (10147-11-2) → 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol (863498-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuI; NEt₃ / PdCl₂(PPh₃)2 / benzene / 4 h / 20 °C

2: 90 percent / tetrahydrofuran / 0.5 h / -78 °C

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; benzene; 1: Sonogashira reaction;

DOI:10.1002/ejoc.200400922

Reference yield:

2-bromocyclohex-1-ene-1-carbaldehyde (38127-47-8) → 1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-ol (863498-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuI; NEt₃ / PdCl₂(PPh₃)2 / benzene / 4 h / 20 °C

2: 90 percent / tetrahydrofuran / 0.5 h / -78 °C

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; benzene; 1: Sonogashira reaction;

DOI:10.1002/ejoc.200400922

upstream raw materials:

2-(3'-phenylprop-1'-ynyl)cyclohex-1-ene-1-carbaldehyde

vinyl magnesium bromide

propargyl benzene

2-bromocyclohex-1-ene-1-carbaldehyde

Downstream raw materials:

4-nitro-1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]pentan-1-one

2-methyl-5-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]-3,4-dihydro-2H-pyrrole N-oxide

1-[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]prop-2-en-1-one