methyl α,β-epoxy-α-methylcinnamate

Base Information

• Chemical Name: methyl α,β-epoxy-α-methylcinnamate
• CAS No.: 80532-66-7
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 80532-66-7.mol

Synonyms:methyl α,β-epoxy-α-methylcinnamate

Chemical Property of methyl α,β-epoxy-α-methylcinnamate

Chemical Property:

• Boiling Point: 73-74 °C(Press: 0.2 Torr)
• Density: 1.168±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

BMK methyl glycidate ≥98% (mixture of cis/trans isomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: BMK methyl glycidate is an analytical reference standard categorized as a precursor in the synthesis of phenylacetone.This product is intended for research and forensic applications. BMK methyl glycidate (Item No. 9002714) is an analytical reference standard categorized as a precursor in the synthesis of phenylacetone (Item Nos. 16103 | 16444). This product is intended for research and forensic applications.
• Uses: 2‐methyl-3-phenyloxirane-2- carboxylic acid (BMK glycidic acid) is substances that is immediate precursors of amphetamines and that is frequently used for the illicit manufacture of amphetamines.

Technology Process of methyl α,β-epoxy-α-methylcinnamate

There total 18 articles about methyl α,β-epoxy-α-methylcinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-propionic acid methyl ester (17639-93-9) + benzaldehyde (100-52-7) → methyl α,β-epoxy-α-methylcinnamate (80532-66-7)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; 1.) 20 deg C, 72 h, 2.) 40 deg C, 24 h;

Reference yield: 80.0%

(E)-methyl-2-methyl-3-phenylacrylate (22946-43-6) → (E)-methyl 2-methyl-3-phenyl-2-oxiranecarboxylate (40956-32-9,40956-33-0,80532-66-7,92817-32-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Heating;

DOI:10.1016/S0022-1139(00)82265-4

Reference yield: 67.0%

methyl 2-methyl-3-phenylacrylate (21370-57-0,22946-43-6,25692-59-5) → methyl α,β-epoxy-α-methylcinnamate (80532-66-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane; for 3h; Reflux;

DOI:10.1016/j.tetlet.2020.152609

upstream raw materials:

2-chloro-propionic acid methyl ester

benzaldehyde

diazomethane

trans-2-methyl-3-phenyloxiranecarboxylic acid

Refernces

• 1、 Zimbron, Jeremy Malcolm,Seeger-Weibel, Manuela,Hirt, Hans,Gallou, Fabrice. "Development of a robust and practical process for the Darzens condensation and α,β-epoxide rearrangement: Scope and limitations of the methodology". . p. 1221 - 1226. Retrieved 2008/12/22.
• 2、 Anisimova, O. S.,Chistyakov, V. V.,Bokanov, A. I.,Shvedov, V. I.,Sheinker, Yu. N.. "MASS SPECTROMETRIC DECOMPOSITION OF β-PHENYLOXIRANECARBOXYLIC ESTERS". . p. 1058 - 1063. Retrieved 2007/10/02.