4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

Base Information

Chemical Name:4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester
CAS No.:133747-64-5
Molecular Formula:C₁₉H₁₈FNO₄
Molecular Weight:343.355
Hs Code.:

Synonyms:4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

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Chemical Property of 4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

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Technology Process of 4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

There total 10 articles about 4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 133747-63-4
1-(4-fluorophenyl)-4-hydroxymethylpyrrolidin-2-one

: 133747-64-5
4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In toluene; at 0 - 80 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: Methanesulfonic acid 1-(4-fluoro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl ester

: 133747-64-5
4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Yield given;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 56617-43-7
1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

: 133747-64-5
4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98.2 percent / conc. H₂SO₄ / CH₂Cl₂ / Heating

2: 99 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

3: Et₃N / CH₂Cl₂

4: K₂CO₃ / dimethylformamide / 80 °C

With methanol; sodium tetrahydroborate; sulfuric acid; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9