8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

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Chemical Name:8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione
CAS No.:1188542-49-5
Molecular Formula:C₂₈H₃₀FN₅O₄
Molecular Weight:519.576
Hs Code.:

Synonyms:8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

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Chemical Property of 8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

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Technology Process of 8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

There total 8 articles about 8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1188542-50-8
N-(6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydropyrimidin-5-yl)-4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]benzamide

: 1188542-49-5
8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Guidance literature:: With sodium hydroxide; In methanol; at 80 ℃; for 7h;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 133747-63-4
1-(4-fluorophenyl)-4-hydroxymethylpyrrolidin-2-one

: 1188542-49-5
8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate; triethylamine / toluene / 24 h / 0 - 80 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 16 h / 25 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 16 h / 25 °C

4: sodium hydroxide / methanol / 7 h / 80 °C

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene; 1: |Mitsunobu Displacement;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 133747-64-5
4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester

: 1188542-49-5
8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 16 h / 25 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 16 h / 25 °C

3: sodium hydroxide / methanol / 7 h / 80 °C

With lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2016.11.007