(4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate

Base Information

• Chemical Name: (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate
• CAS No.: 123642-54-6
• Molecular Formula: C₁₈H₂₆N₂O₈
• Molecular Weight: 398.413
• Mol file: 123642-54-6.mol

Synonyms:(4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate

Chemical Property of (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate

There total 5 articles about (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) + 6-nitroveratrylbromide (53413-67-5) → (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate (123642-54-6)

Guidance literature:

With potassium fluoride; In acetone; at 50 ℃; for 16h;

DOI:10.1021/jo00292a038

Reference yield: 70.0%

N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) + 6-nitroveratryl alcohol (1016-58-6) → (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate (123642-54-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Inert atmosphere;

DOI:10.1039/c1cc15135e

Reference yield:

6-nitroveratryl alcohol (1016-58-6) → (4,5-dimethoxy-2-nitrophenyl)methyl 4butanoate (123642-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 64.6 percent / PBr₃, pyridine / benzene / 24 h

2: 85 percent / KF / acetone / 16 h / 50 °C

With pyridine; potassium fluoride; phosphorus tribromide; In acetone; benzene;

DOI:10.1021/jo00292a038

upstream raw materials:

N-(tert-butoxycarbonyl)-4-aminobutanoic acid

6-nitroveratrylbromide

6-nitroveratryl alcohol

6-nitroveratraldehyde

Downstream raw materials:

(4,5-dimethoxy-2-nitrophenyl)methyl 4-aminobutanoate monohdrochloride