7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Name:7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
CAS No.:1001399-59-2
Molecular Formula:C₁₄H₁₅FN₄O₃S
Molecular Weight:338.363
Hs Code.:

Synonyms:7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Property of 7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Technology Process of 7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

There total 6 articles about 7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001399-55-8
methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-thioxo-3-pyrrolidinecarboxylate

: 22661-87-6,21770-81-0
1-methylguanidine hydrochloride

: 1001399-59-2
7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: 1-methylguanidine hydrochloride; With sodium methylate; In methanol; at 20 ℃; for 0.5h;

methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-thioxo-3-pyrrolidinecarboxylate; In methanol; at 60 - 90 ℃; for 1.08333h;

With hydrogenchloride; In methanol; water; at 20 ℃; for 18h; pH=6;

Reference yield:

: 16019-30-0
6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone

: 1001399-59-2
7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 4 h / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: acetonitrile / 3 h / 60 °C / Inert atmosphere

3.2: 5 h / 70 °C

4.1: sulfuric acid / methanol / 2 h / Reflux

5.1: tetraphosphorus decasulfide / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere

6.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

6.2: 1 h / 60 - 90 °C

With tetraphosphorus decasulfide; sulfuric acid; sodium methylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm301404a

Reference yield:

: 16019-31-1
5-allyl-4,6-dichloropyrimidine

: 1001399-59-2
7-[2-fluoro-4-(methylsulfonyl)phenyl]-2-(methylamino)-1,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.1: acetonitrile / 3 h / 60 °C / Inert atmosphere

2.2: 5 h / 70 °C

3.1: sulfuric acid / methanol / 2 h / Reflux

4.1: tetraphosphorus decasulfide / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere

5.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

5.2: 1 h / 60 - 90 °C

With tetraphosphorus decasulfide; sulfuric acid; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm301404a